| Título : |
Neuroprotective Therapy for Stroke and Ischemic Disease |
| Tipo de documento: |
documento electrónico |
| Autores: |
Lapchak, Paul A., ; Zhang, John H., |
| Mención de edición: |
1 ed. |
| Editorial: |
[s.l.] : Springer |
| Fecha de publicación: |
2017 |
| Número de páginas: |
XVII, 795 p. 105 ilustraciones, 71 ilustraciones en color. |
| ISBN/ISSN/DL: |
978-3-319-45345-3 |
| Nota general: |
Libro disponible en la plataforma SpringerLink. Descarga y lectura en formatos PDF, HTML y ePub. Descarga completa o por capítulos. |
| Palabras clave: |
Neurociencias Cardiología Neurociencia |
| Índice Dewey: |
612.8 Funciones nerviosas. |
| Resumen: |
Este libro es una mirada crítica y completa a la investigación científica y traslacional de vanguardia que se lleva a cabo a nivel internacional, tanto en el mundo académico como en la industria; sirve para abordar nuevas formas de proporcionar un tratamiento eficaz a las víctimas de accidentes cerebrovasculares isquémicos y hemorrágicos y otras enfermedades isquémicas. Actualmente, el ictus se puede tratar con éxito mediante la administración de un trombolítico, pero la ventana terapéutica es corta y muchos pacientes no pueden recibir tratamiento. Sólo alrededor del 30% de los pacientes se "curan" con los tratamientos disponibles. Dividido en cinco secciones, el volumen propuesto explora mecanismos y objetivos de neuroprotección históricos y novedosos, terapias nuevas y combinadas, así como el diseño de ensayos clínicos para algunas de las investigaciones más recientes. |
| Nota de contenido: |
Reflections on Neuroprotection Research and the Path Toward Clinical Success -- Systematic review & meta-analysis: important tools in understanding -- Neuroprotection is Technology, not Science -- History of Experimental Stroke Research -- History of Neuroprotection: Trials and Tribulations -- Targeting PSD-95 As a Novel Approach in the Treatment of Stroke -- ATP Sensitive Potassium Channels (KATP) Play a Role in Hypoxic Preconditioning against Neonatal Hypoxic-Ischemic Brain Injury -- Targeting Oxidative Stress in Stroke -- Nitrones, Old Fellows for New Therapies in Ischemic Stroke -- Neuroprotective strategies via modulation of innate immune receptors -- Harnessing the power of the human immune system via multi-omic immune profiling in stroke treatment and recovery -- Polarization of microglia/macrophages in brain ischemia: relevance for stroke therapy -- Endoplasmic Reticulum Stress: An Opportunity for Neuroprotective Strategies after Stroke -- Effects of Neuroprotectants before and after stroke: Statins and Anti-Hypertensives -- Toward Effective Combination Therapy and Pleiotropic Drugs -- TRPM7 Channels as Potential Therapeutic Targets for Stroke Cholinergic Protection in Ischemic Brain Injury -- Remote Ischemic Conditioning: A Highly Translatable Therapy for Acute Stroke -- Hypothermia for Acute Ischemic Stroke -- Modern endovascular treatment of ischemic disease -- Cerebral Microbleeds and Thrombolysis for Acute Ischemic Stroke -- Targeting pericytes and the microcirculation for ischemic stroke therapy -- Thrombolytic and Endovascular Therapies for Acute Ischemic Stroke -- Sonothrombolysis for acute ischemic stroke: a critical appraisal -- Combination Therapy with Thrombolysis -- Oxygen Carriers: Are they enough for cellular support? -- A new paradigm in protecting ischemic brain: preserving the neurovascular unit before reperfusion -- The right rodent for the job: infarct variability between strains and its impact on logistics of experimental animalstudies -- Rabbit Spinal Cord Ischemia Model for the Development of Neuroprotective Treatments -- Stroke Sex Differences: from basic research to clinical trials -- Unpuzzling the co-morbid type 2 diabetes and hypertension-related cognitive dysfunction and stroke -- Sex Specific Factors in Stroke -- Current Imaging Strategies for Patient Selection in Acute Ischemic Stroke Trials. |
| En línea: |
https://link-springer-com.biblioproxy.umanizales.edu.co/referencework/10.1007/97 [...] |
| Link: |
https://biblioteca.umanizales.edu.co/ils/opac_css/index.php?lvl=notice_display&i |
Neuroprotective Therapy for Stroke and Ischemic Disease [documento electrónico] / Lapchak, Paul A., ; Zhang, John H., . - 1 ed. . - [s.l.] : Springer, 2017 . - XVII, 795 p. 105 ilustraciones, 71 ilustraciones en color. ISBN : 978-3-319-45345-3 Libro disponible en la plataforma SpringerLink. Descarga y lectura en formatos PDF, HTML y ePub. Descarga completa o por capítulos.
| Palabras clave: |
Neurociencias Cardiología Neurociencia |
| Índice Dewey: |
612.8 Funciones nerviosas. |
| Resumen: |
Este libro es una mirada crítica y completa a la investigación científica y traslacional de vanguardia que se lleva a cabo a nivel internacional, tanto en el mundo académico como en la industria; sirve para abordar nuevas formas de proporcionar un tratamiento eficaz a las víctimas de accidentes cerebrovasculares isquémicos y hemorrágicos y otras enfermedades isquémicas. Actualmente, el ictus se puede tratar con éxito mediante la administración de un trombolítico, pero la ventana terapéutica es corta y muchos pacientes no pueden recibir tratamiento. Sólo alrededor del 30% de los pacientes se "curan" con los tratamientos disponibles. Dividido en cinco secciones, el volumen propuesto explora mecanismos y objetivos de neuroprotección históricos y novedosos, terapias nuevas y combinadas, así como el diseño de ensayos clínicos para algunas de las investigaciones más recientes. |
| Nota de contenido: |
Reflections on Neuroprotection Research and the Path Toward Clinical Success -- Systematic review & meta-analysis: important tools in understanding -- Neuroprotection is Technology, not Science -- History of Experimental Stroke Research -- History of Neuroprotection: Trials and Tribulations -- Targeting PSD-95 As a Novel Approach in the Treatment of Stroke -- ATP Sensitive Potassium Channels (KATP) Play a Role in Hypoxic Preconditioning against Neonatal Hypoxic-Ischemic Brain Injury -- Targeting Oxidative Stress in Stroke -- Nitrones, Old Fellows for New Therapies in Ischemic Stroke -- Neuroprotective strategies via modulation of innate immune receptors -- Harnessing the power of the human immune system via multi-omic immune profiling in stroke treatment and recovery -- Polarization of microglia/macrophages in brain ischemia: relevance for stroke therapy -- Endoplasmic Reticulum Stress: An Opportunity for Neuroprotective Strategies after Stroke -- Effects of Neuroprotectants before and after stroke: Statins and Anti-Hypertensives -- Toward Effective Combination Therapy and Pleiotropic Drugs -- TRPM7 Channels as Potential Therapeutic Targets for Stroke Cholinergic Protection in Ischemic Brain Injury -- Remote Ischemic Conditioning: A Highly Translatable Therapy for Acute Stroke -- Hypothermia for Acute Ischemic Stroke -- Modern endovascular treatment of ischemic disease -- Cerebral Microbleeds and Thrombolysis for Acute Ischemic Stroke -- Targeting pericytes and the microcirculation for ischemic stroke therapy -- Thrombolytic and Endovascular Therapies for Acute Ischemic Stroke -- Sonothrombolysis for acute ischemic stroke: a critical appraisal -- Combination Therapy with Thrombolysis -- Oxygen Carriers: Are they enough for cellular support? -- A new paradigm in protecting ischemic brain: preserving the neurovascular unit before reperfusion -- The right rodent for the job: infarct variability between strains and its impact on logistics of experimental animalstudies -- Rabbit Spinal Cord Ischemia Model for the Development of Neuroprotective Treatments -- Stroke Sex Differences: from basic research to clinical trials -- Unpuzzling the co-morbid type 2 diabetes and hypertension-related cognitive dysfunction and stroke -- Sex Specific Factors in Stroke -- Current Imaging Strategies for Patient Selection in Acute Ischemic Stroke Trials. |
| En línea: |
https://link-springer-com.biblioproxy.umanizales.edu.co/referencework/10.1007/97 [...] |
| Link: |
https://biblioteca.umanizales.edu.co/ils/opac_css/index.php?lvl=notice_display&i |
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Neuroprotective Therapy for Stroke and Ischemic Disease
