TÃtulo : |
Antimicrobial Peptides : Basics for Clinical Application |
Tipo de documento: |
documento electrónico |
Autores: |
Matsuzaki, Katsumi, |
Mención de edición: |
1 ed. |
Editorial: |
Singapore [Malasya] : Springer |
Fecha de publicación: |
2019 |
Número de páginas: |
VIII, 304 p. 73 ilustraciones, 55 ilustraciones en color. |
ISBN/ISSN/DL: |
978-981-1335884-- |
Nota general: |
Libro disponible en la plataforma SpringerLink. Descarga y lectura en formatos PDF, HTML y ePub. Descarga completa o por capítulos. |
Idioma : |
Inglés (eng) |
Palabras clave: |
FarmacologÃa BiofÃsica BioquÃmica Cáncer BiologÃa del cáncer |
Clasificación: |
615 Medicina (Farmacología terapéutica) |
Resumen: |
Este libro presenta una descripción general de los péptidos antimicrobianos (AMP), sus mecanismos de acción antimicrobiana, otras actividades y diversos problemas que aún deben superarse con respecto a su aplicación clÃnica. Dividido en cuatro partes principales, el libro comienza con una descripción general de los AMP (Parte I) y posteriormente analiza los diversos mecanismos de acción antimicrobiana y los métodos para investigarlos (Parte 2). Luego aborda una variedad de actividades distintas a la acción antimicrobiana, como la penetración celular, la antisepsia, las actividades anticancerÃgenas y inmunomoduladoras (Parte 3), y explora las perspectivas de aplicación clÃnica desde varios puntos de vista, como la toxicidad selectiva, el diseño y el descubrimiento de AMP (Parte 4). Se ha descubierto una gran cantidad de AMP en plantas, insectos y vertebrados, incluidos los humanos, y constituyen sistemas de defensa del huésped contra microorganismos patógenos invasores. En consecuencia, se han realizado muchos intentos de utilizar AMP como antibióticos. Los AMP podrÃan ayudar a resolver el urgente problema de las bacterias resistentes a los medicamentos y también son prometedores en lo que respecta a la sepsis y la terapia contra el cáncer. Al recopilar una gran cantidad de información, este libro será una biblia para todos aquellos que buscan desarrollar antibióticos, antisepsia o agentes anticancerÃgenos basados ​​en AMP. |
Nota de contenido: |
Part 1. Introduction -- Chapter 1. Antimicrobial peptides of multicellular organisms: My perspective -- Part 2. Mechanisms of Antimicrobial Action -- Chapter 2. Membrane permeabilization mechanisms -- Chapter 3. Elementary processes and mechanisms of interactions of antimicrobial peptides with membranes --- single GUV studies ---- -- Chapter 4. The mechanisms of action of cationic antimicrobial peptides refined by novel concepts from biophysical investigations -- Chapter 5. Anionic lipid clustering model -- Chapter 6. Intracellular antimicrobial peptides targeting the protein synthesis machinery -- Part 3. Other activities of AMPs -- Chapter 7. Antimicrobial and cell-penetrating peptides: How to understand two distinct functions despite similar physicochemical properties -- Chapter 8. Synthetic anti-lipopolysaccharide peptides (SALP) as effective inhibitors of pathogen-associated molecular patterns (PAMPs) -- Chapter 9. Anti-cancer activities of natural and synthetic peptides -- Chapter 10. Antimicrobial host defence peptides: Immunomodulatory functions and translational prospects -- Part 4. Towards Clinical Applications -- Chapter 11. Activity and selectivity of antimicrobial peptides: A complex interplay of multiple equilibria -- Chapter 12. Design of antimicrobial peptides: Progress made with human cathelicidin LL-37 -- Chapter 13. Application of synthetic molecular evolution to the discovery of antimicrobial peptides -- Chapter 14. AMPs as anti-biofilm agents for human therapy and prophylaxis -- Chapter 15. Clinical application of AMPs. . |
Tipo de medio : |
Computadora |
Summary : |
This book presents an overview of antimicrobial peptides (AMPs), their mechanisms of antimicrobial action, other activities, and various problems that must still be overcome regarding their clinical application. Divided into four major parts, the book begins with a general overview of AMPs (Part I), and subsequently discusses the various mechanisms of antimicrobial action and methods for researching them (Part 2). It then addresses a range of activities other than antimicrobial action, such as cell penetration, antisepsis, anticancer, and immunomodulatory activities (Part 3), and explores the prospects of clinical application from various standpoints such as the selective toxicity, design, and discovery of AMPs (Part 4). A huge number of AMPs have been discovered in plants, insects, and vertebrates including humans, and constitute host defense systems against invading pathogenic microorganisms. Consequently, many attempts have been made to utilize AMPs as antibiotics. AMPs could help to solve the urgent problem of drug-resistant bacteria, and are also promising with regard to sepsis and cancer therapy. Gathering a wealth of information, this book will be a bible for all those seeking to develop antibiotics, anti-sepsis, or anticancer agents based on AMPs. |
Enlace de acceso : |
https://link-springer-com.biblioproxy.umanizales.edu.co/referencework/10.1007/97 [...] |
Antimicrobial Peptides : Basics for Clinical Application [documento electrónico] / Matsuzaki, Katsumi, . - 1 ed. . - Singapore [Malasya] : Springer, 2019 . - VIII, 304 p. 73 ilustraciones, 55 ilustraciones en color. ISBN : 978-981-1335884-- Libro disponible en la plataforma SpringerLink. Descarga y lectura en formatos PDF, HTML y ePub. Descarga completa o por capítulos. Idioma : Inglés ( eng)
Palabras clave: |
FarmacologÃa BiofÃsica BioquÃmica Cáncer BiologÃa del cáncer |
Clasificación: |
615 Medicina (Farmacología terapéutica) |
Resumen: |
Este libro presenta una descripción general de los péptidos antimicrobianos (AMP), sus mecanismos de acción antimicrobiana, otras actividades y diversos problemas que aún deben superarse con respecto a su aplicación clÃnica. Dividido en cuatro partes principales, el libro comienza con una descripción general de los AMP (Parte I) y posteriormente analiza los diversos mecanismos de acción antimicrobiana y los métodos para investigarlos (Parte 2). Luego aborda una variedad de actividades distintas a la acción antimicrobiana, como la penetración celular, la antisepsia, las actividades anticancerÃgenas y inmunomoduladoras (Parte 3), y explora las perspectivas de aplicación clÃnica desde varios puntos de vista, como la toxicidad selectiva, el diseño y el descubrimiento de AMP (Parte 4). Se ha descubierto una gran cantidad de AMP en plantas, insectos y vertebrados, incluidos los humanos, y constituyen sistemas de defensa del huésped contra microorganismos patógenos invasores. En consecuencia, se han realizado muchos intentos de utilizar AMP como antibióticos. Los AMP podrÃan ayudar a resolver el urgente problema de las bacterias resistentes a los medicamentos y también son prometedores en lo que respecta a la sepsis y la terapia contra el cáncer. Al recopilar una gran cantidad de información, este libro será una biblia para todos aquellos que buscan desarrollar antibióticos, antisepsia o agentes anticancerÃgenos basados ​​en AMP. |
Nota de contenido: |
Part 1. Introduction -- Chapter 1. Antimicrobial peptides of multicellular organisms: My perspective -- Part 2. Mechanisms of Antimicrobial Action -- Chapter 2. Membrane permeabilization mechanisms -- Chapter 3. Elementary processes and mechanisms of interactions of antimicrobial peptides with membranes --- single GUV studies ---- -- Chapter 4. The mechanisms of action of cationic antimicrobial peptides refined by novel concepts from biophysical investigations -- Chapter 5. Anionic lipid clustering model -- Chapter 6. Intracellular antimicrobial peptides targeting the protein synthesis machinery -- Part 3. Other activities of AMPs -- Chapter 7. Antimicrobial and cell-penetrating peptides: How to understand two distinct functions despite similar physicochemical properties -- Chapter 8. Synthetic anti-lipopolysaccharide peptides (SALP) as effective inhibitors of pathogen-associated molecular patterns (PAMPs) -- Chapter 9. Anti-cancer activities of natural and synthetic peptides -- Chapter 10. Antimicrobial host defence peptides: Immunomodulatory functions and translational prospects -- Part 4. Towards Clinical Applications -- Chapter 11. Activity and selectivity of antimicrobial peptides: A complex interplay of multiple equilibria -- Chapter 12. Design of antimicrobial peptides: Progress made with human cathelicidin LL-37 -- Chapter 13. Application of synthetic molecular evolution to the discovery of antimicrobial peptides -- Chapter 14. AMPs as anti-biofilm agents for human therapy and prophylaxis -- Chapter 15. Clinical application of AMPs. . |
Tipo de medio : |
Computadora |
Summary : |
This book presents an overview of antimicrobial peptides (AMPs), their mechanisms of antimicrobial action, other activities, and various problems that must still be overcome regarding their clinical application. Divided into four major parts, the book begins with a general overview of AMPs (Part I), and subsequently discusses the various mechanisms of antimicrobial action and methods for researching them (Part 2). It then addresses a range of activities other than antimicrobial action, such as cell penetration, antisepsis, anticancer, and immunomodulatory activities (Part 3), and explores the prospects of clinical application from various standpoints such as the selective toxicity, design, and discovery of AMPs (Part 4). A huge number of AMPs have been discovered in plants, insects, and vertebrates including humans, and constitute host defense systems against invading pathogenic microorganisms. Consequently, many attempts have been made to utilize AMPs as antibiotics. AMPs could help to solve the urgent problem of drug-resistant bacteria, and are also promising with regard to sepsis and cancer therapy. Gathering a wealth of information, this book will be a bible for all those seeking to develop antibiotics, anti-sepsis, or anticancer agents based on AMPs. |
Enlace de acceso : |
https://link-springer-com.biblioproxy.umanizales.edu.co/referencework/10.1007/97 [...] |
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