Scleroderma / Varga, John ; Denton, Christopher P. ; Wigley, Fredrick M. ; Allanore, Yannick ; Kuwana, Masataka  

Público ISBD Ningún comentario para este registro. Título : Scleroderma : From Pathogenesis to Comprehensive Management Tipo de documento: documento electrónico Autores: Varga, John, ; Denton, Christopher P., ; Wigley, Fredrick M., ; Allanore, Yannick, ; Kuwana, Masataka, Mención de edición: 2 ed. Editorial: [s.l.] : Springer Fecha de publicación: 2017 Número de páginas: XXXV, 743 p. 191 ilustraciones, 174 ilustraciones en color. ISBN/ISSN/DL: 978-3-319-31407-5 Nota general: Libro disponible en la plataforma SpringerLink. Descarga y lectura en formatos PDF, HTML y ePub. Descarga completa o por capítulos. Idioma : Inglés (eng) Palabras clave: Reumatología  Órganos respiratorios  Dermatología  Neumología Clasificación: 616.723 Resumen: Compuesta por el trabajo autorizado de expertos internacionales, esta segunda edición completamente actualizada de Escleroderma se basa en el enfoque bien considerado de la primera edición para proporcionar una síntesis integrada, concisa y actualizada de los conceptos actuales de patogénesis y enfoques modernos para Manejo de la esclerosis sistémica (esclerodermia). Con un enfoque multidisciplinario de la atención integral, este libro es de fácil acceso para profesionales de la salud en muchos campos. La nueva edición incluye material extenso y actualizado basado en los principales avances en el campo, con nuevos capítulos sobre medicina personalizada, complicaciones del cáncer, perspectivas globales sobre la esclerodermia y más. Presenta una síntesis sucinta y reflexiva de los conceptos patomecanicistas actuales, proporcionando una valiosa herramienta de referencia para los investigadores básicos y traslacionales que trabajan en este campo. Esclerodermia: de la patogénesis al tratamiento integral sirve como un recurso esencial e integral para reumatólogos, neumólogos, cardiólogos, gastroenterólogos, nefrólogos y todos aquellos involucrados en el cuidado de pacientes con esclerodermia. Nota de contenido: Section I. Introduction -- Historical Perspective of Scleroderma -- Section II. Epidemiology, Genetics and Classification -- Epidemiology, Environmental and Infectious Risk Factors -- Genetic Factors -- Disease Subsets in Clinical Practice -- Evolving Concepts of Diagnosis and Classification -- Overlap Syndromes -- Juvenile Localized and Systemic Scleroderma -- Morphea (Localized Scleroderma) -- Scleroderma Mimics -- Systems Biology Approaches to Understanding the Pathogenesis of Systemic Sclerosis -- Section III: The Biological Basis of Systemic Sclerosis -- Introduction: The Etiopathogenesis of Systemic Sclerosis: An Integrated Overview -- Pathology of Systemic Sclerosis -- Inflammation and Immunity -- Autoantibodies as Markers and Possible Mediators of Scleroderma Pathogenesis -- The Clinical Aspects of Autoantibodies -- Mechanisms of Vascular Disease -- Biomarkers in Systemic Sclerosis -- Pathophysiology of Fibrosis in Systemic Sclerosis -- Overview of Animal Models -- Section IV. Cardiovascular Manifestations and Management -- Raynaud's Phenomenon, Digital Ulcers, and Nailfold Capillaroscopy -- Renal Crisis and Other Renal Manifestations of Scleroderma -- Cardiac Involvement -- Section V. Pulmonary Manifestations and Management -- Overview of Lung Involvement: Diagnosis, Differential Diagnosis, and Monitoring -- Clinical Assessment of Lung Disease -- Treatment of Interstitial Lung Disease -- Pathogenesis of Pulmonary Arterial Hypertension -- Clinical Assessment of Pulmonary Hypertension -- The Management of Pulmonary Arterial Hypertension in the Setting of Systemic Sclerosis -- Section VI. Gastrointestinal Manifestations and Management -- Overview of Gastrointestinal Tract Involvement -- Upper Gastrointestinal Tract: Manifestations of Systemic Sclerosis -- Small and Large Intestinal Involvement and Nutritional Issues -- Section VII. Skin, Musculoskeletal and Other Complications -- Calcinosis -- Evaluation and Management of Skin Disease -- Assessment and Management of Progressive Skin Involvement in Diffuse Scleroderma -- Skeletal Muscle Involvement -- Tendons, Joints, and Bone -- Cancer in Systemic Sclerosis -- Overlooked Manifestations -- Pregnancy -- Section VIII: Management and Outcome Assessment -- Introduction to Section VIII: Management and Outcome Assessment -- Immunomodulatory, Immunoablative, and Biologic Therapies -- Investigative Approaches to Drug Therapy -- Drug Development and Regulatory Considerations for SSc Therapies -- Physical and Occupational Therapy -- Psychosocial Issues and Care for Patients with Systemic Sclerosis -- Clinical Trial Design in Systemic Sclerosis -- Measuring Disease Activity and Outcomes in Clinical Trials -- Innovative Approaches to Clinical Trials in Systemic Sclerosis -- Molecular Stratification by Gene Expression as a Paradigm for Precision Medicine in Systemic Sclerosis -- Section IX. Case Studies: Approach to Complex Clinical Problems -- Managing the Ischemic Finger in Scleroderma -- Scleroderma Renal Crisis -- Rapid Diffuse Skin Disease with Progressive Joint Contractures -- Management of the Scleroderma Patient with Pulmonary Arterial Hypertension Failing Initial Therapy -- Pseudo-obstruction with Malabsorption and Malnutrition -- Progressive Interstitial Lung Disease Non-Response to Cyclophosphamide -- Coping with the Disfigurement of Scleroderma: Facial, Skin, and Hand Changes -- Managing Complicated Digital Ulcers . Tipo de medio : Computadora Summary : Comprised of the authoritative work of international experts, this fully-updated second edition of Scleroderma builds upon the well-regarded approach in the first edition to provide integrated, concise, and up-to-date synthesis of current concepts of pathogenesis and modern approaches to management of systemic sclerosis (scleroderma). With a multidisciplinary approach to comprehensive care, this book is easily accessible for health care professionals in many fields. The new edition includes extensive updated material based on major developments in the field, with new chapters on personalized medicine, cancer complications, global perspectives on scleroderma, and more. It presents a succinct and thoughtful synthesis of current pathomechanistic concepts, providing a valuable reference tool for basic and translational investigators working in the field. Scleroderma: From Pathogenesis to Comprehensive Management serves as an essential, all-inclusive resource for rheumatologists, pulmonologists, cardiologists, gastroenterologists, nephrologists and all those involved in the care of scleroderma patients. Enlace de acceso : https://link-springer-com.biblioproxy.umanizales.edu.co/referencework/10.1007/97 [...] Scleroderma : From Pathogenesis to Comprehensive Management [documento electrónico] / Varga, John, ; Denton, Christopher P., ; Wigley, Fredrick M., ; Allanore, Yannick, ; Kuwana, Masataka,  . -  2 ed.  . - [s.l.] : Springer, 2017 . - XXXV, 743 p. 191 ilustraciones, 174 ilustraciones en color. ISBN : 978-3-319-31407-5 Libro disponible en la plataforma SpringerLink. Descarga y lectura en formatos PDF, HTML y ePub. Descarga completa o por capítulos. Idioma : Inglés (eng) Palabras clave: Reumatología  Órganos respiratorios  Dermatología  Neumología Clasificación: 616.723 Resumen: Compuesta por el trabajo autorizado de expertos internacionales, esta segunda edición completamente actualizada de Escleroderma se basa en el enfoque bien considerado de la primera edición para proporcionar una síntesis integrada, concisa y actualizada de los conceptos actuales de patogénesis y enfoques modernos para Manejo de la esclerosis sistémica (esclerodermia). Con un enfoque multidisciplinario de la atención integral, este libro es de fácil acceso para profesionales de la salud en muchos campos. La nueva edición incluye material extenso y actualizado basado en los principales avances en el campo, con nuevos capítulos sobre medicina personalizada, complicaciones del cáncer, perspectivas globales sobre la esclerodermia y más. Presenta una síntesis sucinta y reflexiva de los conceptos patomecanicistas actuales, proporcionando una valiosa herramienta de referencia para los investigadores básicos y traslacionales que trabajan en este campo. Esclerodermia: de la patogénesis al tratamiento integral sirve como un recurso esencial e integral para reumatólogos, neumólogos, cardiólogos, gastroenterólogos, nefrólogos y todos aquellos involucrados en el cuidado de pacientes con esclerodermia. Nota de contenido: Section I. Introduction -- Historical Perspective of Scleroderma -- Section II. Epidemiology, Genetics and Classification -- Epidemiology, Environmental and Infectious Risk Factors -- Genetic Factors -- Disease Subsets in Clinical Practice -- Evolving Concepts of Diagnosis and Classification -- Overlap Syndromes -- Juvenile Localized and Systemic Scleroderma -- Morphea (Localized Scleroderma) -- Scleroderma Mimics -- Systems Biology Approaches to Understanding the Pathogenesis of Systemic Sclerosis -- Section III: The Biological Basis of Systemic Sclerosis -- Introduction: The Etiopathogenesis of Systemic Sclerosis: An Integrated Overview -- Pathology of Systemic Sclerosis -- Inflammation and Immunity -- Autoantibodies as Markers and Possible Mediators of Scleroderma Pathogenesis -- The Clinical Aspects of Autoantibodies -- Mechanisms of Vascular Disease -- Biomarkers in Systemic Sclerosis -- Pathophysiology of Fibrosis in Systemic Sclerosis -- Overview of Animal Models -- Section IV. Cardiovascular Manifestations and Management -- Raynaud's Phenomenon, Digital Ulcers, and Nailfold Capillaroscopy -- Renal Crisis and Other Renal Manifestations of Scleroderma -- Cardiac Involvement -- Section V. Pulmonary Manifestations and Management -- Overview of Lung Involvement: Diagnosis, Differential Diagnosis, and Monitoring -- Clinical Assessment of Lung Disease -- Treatment of Interstitial Lung Disease -- Pathogenesis of Pulmonary Arterial Hypertension -- Clinical Assessment of Pulmonary Hypertension -- The Management of Pulmonary Arterial Hypertension in the Setting of Systemic Sclerosis -- Section VI. Gastrointestinal Manifestations and Management -- Overview of Gastrointestinal Tract Involvement -- Upper Gastrointestinal Tract: Manifestations of Systemic Sclerosis -- Small and Large Intestinal Involvement and Nutritional Issues -- Section VII. Skin, Musculoskeletal and Other Complications -- Calcinosis -- Evaluation and Management of Skin Disease -- Assessment and Management of Progressive Skin Involvement in Diffuse Scleroderma -- Skeletal Muscle Involvement -- Tendons, Joints, and Bone -- Cancer in Systemic Sclerosis -- Overlooked Manifestations -- Pregnancy -- Section VIII: Management and Outcome Assessment -- Introduction to Section VIII: Management and Outcome Assessment -- Immunomodulatory, Immunoablative, and Biologic Therapies -- Investigative Approaches to Drug Therapy -- Drug Development and Regulatory Considerations for SSc Therapies -- Physical and Occupational Therapy -- Psychosocial Issues and Care for Patients with Systemic Sclerosis -- Clinical Trial Design in Systemic Sclerosis -- Measuring Disease Activity and Outcomes in Clinical Trials -- Innovative Approaches to Clinical Trials in Systemic Sclerosis -- Molecular Stratification by Gene Expression as a Paradigm for Precision Medicine in Systemic Sclerosis -- Section IX. Case Studies: Approach to Complex Clinical Problems -- Managing the Ischemic Finger in Scleroderma -- Scleroderma Renal Crisis -- Rapid Diffuse Skin Disease with Progressive Joint Contractures -- Management of the Scleroderma Patient with Pulmonary Arterial Hypertension Failing Initial Therapy -- Pseudo-obstruction with Malabsorption and Malnutrition -- Progressive Interstitial Lung Disease Non-Response to Cyclophosphamide -- Coping with the Disfigurement of Scleroderma: Facial, Skin, and Hand Changes -- Managing Complicated Digital Ulcers . Tipo de medio : Computadora Summary : Comprised of the authoritative work of international experts, this fully-updated second edition of Scleroderma builds upon the well-regarded approach in the first edition to provide integrated, concise, and up-to-date synthesis of current concepts of pathogenesis and modern approaches to management of systemic sclerosis (scleroderma). With a multidisciplinary approach to comprehensive care, this book is easily accessible for health care professionals in many fields. The new edition includes extensive updated material based on major developments in the field, with new chapters on personalized medicine, cancer complications, global perspectives on scleroderma, and more. It presents a succinct and thoughtful synthesis of current pathomechanistic concepts, providing a valuable reference tool for basic and translational investigators working in the field. Scleroderma: From Pathogenesis to Comprehensive Management serves as an essential, all-inclusive resource for rheumatologists, pulmonologists, cardiologists, gastroenterologists, nephrologists and all those involved in the care of scleroderma patients. Enlace de acceso : https://link-springer-com.biblioproxy.umanizales.edu.co/referencework/10.1007/97 [...]

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