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Autor Jurga, Stefan |
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Título : Epitranscriptomics Tipo de documento: documento electrónico Autores: Jurga, Stefan, ; Barciszewski, Jan, Mención de edición: 1 ed. Editorial: [s.l.] : Springer Fecha de publicación: 2021 Número de páginas: X, 632 p. 90 ilustraciones, 84 ilustraciones en color. ISBN/ISSN/DL: 978-3-030-71612-7 Nota general: Libro disponible en la plataforma SpringerLink. Descarga y lectura en formatos PDF, HTML y ePub. Descarga completa o por capítulos. Idioma : Inglés (eng) Palabras clave: Epigenética ARN Bioquímica Bioinformática Metabolismo del ARN Química biológica Clasificación: 572.865 Resumen: Este libro analiza un campo novedoso y apasionante de la biología celular y molecular llamado epitranscriptómica, que se centra en los cambios en las células de un organismo resultantes de la modificación postranscripcional del ARN celular. Las proteínas de unión a ARN (RBP) desempeñan un papel crucial en estas modificaciones postranscripcionales y también apoyan varios procesos celulares necesarios para mantener la homeostasis del ARN. Explorar los mecanismos subyacentes a las modificaciones del ARN y la función de la RBP es un área emergente de la investigación biomédica, que lleva el estudio de la regulación genética un paso más allá de la epigenética. Este libro revela que la molécula de ARN no es sólo una molécula portadora de información con algunas estructuras secundarias. En consecuencia, un aspecto importante es cómo se modifica, regula, empaqueta y controla el ARN. Los principales expertos abordan preguntas como dónde se ubican en el genoma las más de 170 modificaciones postranscripcionales distintas del ARN, qué porcentaje de ARNm y ARN no codificantes incluyen estas modificaciones y cómo una modificación del ARN afecta la biología de una persona. Para concluir, el libro revisa el papel de las modificaciones del ARN y las RBP en una variedad de enfermedades y su patogénesis. Este libro, que aborda algunos de los desafíos más interesantes de la epitranscriptómica, proporciona un recurso valioso y atractivo para los investigadores del mundo académico y de la industria que estudian los fenómenos de la modificación del ARN. Nota de contenido: Epitranscriptomic Modifications and How to Find them -- Epitranscriptomic Signature in Neural Development and Disease -- The Emerging Neuroepitranscriptome -- Epitranscriptomics and Diseases -- Epitranscriptomic Marks and Systems Involved in Gene Regulation, Development and Disease -- Experimental Approaches and Computational Workflows for Systematic Mapping and Functional Interpretation of RNA Modifications -- RNA Modifications: The Mediator Between Cellular Stresses and Biological Effects -- Computational Prediction and Experimental Validation of Specific Modified RNA Sites -- Regulation of RNA Stability Utilizing RNA Modification -- Dynamic RNA Modification Upon Extracellular Stimulus -- RNA Methylation in Cancer -- Regulation of RNA Methylation yy TET Enzymes -- RNA N6-Methyladenosine and G-Quadruplex Structures in Bacteria -- RNA N6-Methyladenosine Chemical Modification as a Therapeutic Target -- Cap-Adjacent m6Am and its Effects On mRNA -- N6-Methyladenosine in The Heart -- The m6a RNA Methylation Regulates Oncogenic Signaling Pathways Driving Cell Transformation and Carcinogenesis -- Psivar: A Database of Functional Variants Involved in Pseudouridylation (Ψ) with Implications for Disease Pathogenesis -- C-to-U RNA Editing by Mammalian APOBEC Enzymes -- The Powerful Mechanism of RNA Editing and its Therapeutic Potentials -- Noncanonical Caps in RNA -- Mass Spectrometry-Based Methods for Characterization of Hypomodifications in tRNA -- Dynamic mRNA Modifications in Plants -- The Mammalian Mitochondrial Epitranscriptome -- Epitranscriptomics Modifications of Micrornas: Classes, Detection, Impact on their Functionality and Next Frontiers -- "Look Before You Leap" when Editing the Introns, or the Secrets Behind the Intronic Post-Transcriptional Modification -- Functional Links Between the Internal N6-Methyl Adenosine Modifications in mRNAs and Human Diseases -- RNA Modifications in Neurodevelopment and Neurodegenerations -- Conventional and Advanced Techniques for Methyl-6-Adenosine Modification Mapping in Transcripts -- Mechanisms and Therapeutic Applications of RNA-Guided RNA Pseudouridylation -- Epitranscriptomic Modifications in lnRNA and miRNA in Cancer and Other Diseases -- RNA m6A and Adipogenesis. Tipo de medio : Computadora Summary : This book reviews a novel and exciting field of cellular and molecular biology called epitranscriptomics, which focuses on changes in an organism's cells resulting from the posttranscriptional modification of cellular RNA. RNA-binding proteins (RBPs) play a crucial role in these posttranscriptional modifications and also support several cellular processes necessary for maintaining RNA homeostasis. Exploring the mechanisms underlying RNA modifications and RBP function is an emerging area of biomedical research, taking the study of gene regulation a step beyond epigenetics. This book reveals that the RNA molecule is not just an information-carrying molecule with some secondary structures. Accordingly, how RNA is modified, regulated, packaged, and controlled is an important aspect. Leading experts address questions such as where the over 170 distinct posttranscriptional RNA modifications are located on the genome, what percentage of mRNAs and noncoding RNAs these modifications include, and how an RNA modification impacts a person's biology. In closing, the book reviews the role of RNA modifications and RBPs in a variety of diseases and their pathogenesis. Addressing some of the most exciting challenges in epitranscriptomics, this book provides a valuable and engaging resource for researchers in academia and industry studying the phenomena of RNA modification. Enlace de acceso : https://link-springer-com.biblioproxy.umanizales.edu.co/referencework/10.1007/97 [...] Epitranscriptomics [documento electrónico] / Jurga, Stefan, ; Barciszewski, Jan, . - 1 ed. . - [s.l.] : Springer, 2021 . - X, 632 p. 90 ilustraciones, 84 ilustraciones en color.
ISBN : 978-3-030-71612-7
Libro disponible en la plataforma SpringerLink. Descarga y lectura en formatos PDF, HTML y ePub. Descarga completa o por capítulos.
Idioma : Inglés (eng)
Palabras clave: Epigenética ARN Bioquímica Bioinformática Metabolismo del ARN Química biológica Clasificación: 572.865 Resumen: Este libro analiza un campo novedoso y apasionante de la biología celular y molecular llamado epitranscriptómica, que se centra en los cambios en las células de un organismo resultantes de la modificación postranscripcional del ARN celular. Las proteínas de unión a ARN (RBP) desempeñan un papel crucial en estas modificaciones postranscripcionales y también apoyan varios procesos celulares necesarios para mantener la homeostasis del ARN. Explorar los mecanismos subyacentes a las modificaciones del ARN y la función de la RBP es un área emergente de la investigación biomédica, que lleva el estudio de la regulación genética un paso más allá de la epigenética. Este libro revela que la molécula de ARN no es sólo una molécula portadora de información con algunas estructuras secundarias. En consecuencia, un aspecto importante es cómo se modifica, regula, empaqueta y controla el ARN. Los principales expertos abordan preguntas como dónde se ubican en el genoma las más de 170 modificaciones postranscripcionales distintas del ARN, qué porcentaje de ARNm y ARN no codificantes incluyen estas modificaciones y cómo una modificación del ARN afecta la biología de una persona. Para concluir, el libro revisa el papel de las modificaciones del ARN y las RBP en una variedad de enfermedades y su patogénesis. Este libro, que aborda algunos de los desafíos más interesantes de la epitranscriptómica, proporciona un recurso valioso y atractivo para los investigadores del mundo académico y de la industria que estudian los fenómenos de la modificación del ARN. Nota de contenido: Epitranscriptomic Modifications and How to Find them -- Epitranscriptomic Signature in Neural Development and Disease -- The Emerging Neuroepitranscriptome -- Epitranscriptomics and Diseases -- Epitranscriptomic Marks and Systems Involved in Gene Regulation, Development and Disease -- Experimental Approaches and Computational Workflows for Systematic Mapping and Functional Interpretation of RNA Modifications -- RNA Modifications: The Mediator Between Cellular Stresses and Biological Effects -- Computational Prediction and Experimental Validation of Specific Modified RNA Sites -- Regulation of RNA Stability Utilizing RNA Modification -- Dynamic RNA Modification Upon Extracellular Stimulus -- RNA Methylation in Cancer -- Regulation of RNA Methylation yy TET Enzymes -- RNA N6-Methyladenosine and G-Quadruplex Structures in Bacteria -- RNA N6-Methyladenosine Chemical Modification as a Therapeutic Target -- Cap-Adjacent m6Am and its Effects On mRNA -- N6-Methyladenosine in The Heart -- The m6a RNA Methylation Regulates Oncogenic Signaling Pathways Driving Cell Transformation and Carcinogenesis -- Psivar: A Database of Functional Variants Involved in Pseudouridylation (Ψ) with Implications for Disease Pathogenesis -- C-to-U RNA Editing by Mammalian APOBEC Enzymes -- The Powerful Mechanism of RNA Editing and its Therapeutic Potentials -- Noncanonical Caps in RNA -- Mass Spectrometry-Based Methods for Characterization of Hypomodifications in tRNA -- Dynamic mRNA Modifications in Plants -- The Mammalian Mitochondrial Epitranscriptome -- Epitranscriptomics Modifications of Micrornas: Classes, Detection, Impact on their Functionality and Next Frontiers -- "Look Before You Leap" when Editing the Introns, or the Secrets Behind the Intronic Post-Transcriptional Modification -- Functional Links Between the Internal N6-Methyl Adenosine Modifications in mRNAs and Human Diseases -- RNA Modifications in Neurodevelopment and Neurodegenerations -- Conventional and Advanced Techniques for Methyl-6-Adenosine Modification Mapping in Transcripts -- Mechanisms and Therapeutic Applications of RNA-Guided RNA Pseudouridylation -- Epitranscriptomic Modifications in lnRNA and miRNA in Cancer and Other Diseases -- RNA m6A and Adipogenesis. Tipo de medio : Computadora Summary : This book reviews a novel and exciting field of cellular and molecular biology called epitranscriptomics, which focuses on changes in an organism's cells resulting from the posttranscriptional modification of cellular RNA. RNA-binding proteins (RBPs) play a crucial role in these posttranscriptional modifications and also support several cellular processes necessary for maintaining RNA homeostasis. Exploring the mechanisms underlying RNA modifications and RBP function is an emerging area of biomedical research, taking the study of gene regulation a step beyond epigenetics. This book reveals that the RNA molecule is not just an information-carrying molecule with some secondary structures. Accordingly, how RNA is modified, regulated, packaged, and controlled is an important aspect. Leading experts address questions such as where the over 170 distinct posttranscriptional RNA modifications are located on the genome, what percentage of mRNAs and noncoding RNAs these modifications include, and how an RNA modification impacts a person's biology. In closing, the book reviews the role of RNA modifications and RBPs in a variety of diseases and their pathogenesis. Addressing some of the most exciting challenges in epitranscriptomics, this book provides a valuable and engaging resource for researchers in academia and industry studying the phenomena of RNA modification. Enlace de acceso : https://link-springer-com.biblioproxy.umanizales.edu.co/referencework/10.1007/97 [...]
Título : Plant Epigenetics Tipo de documento: documento electrónico Autores: Rajewsky, Nikolaus, ; Jurga, Stefan, ; Barciszewski, Jan, Mención de edición: 1 ed. Editorial: [s.l.] : Springer Fecha de publicación: 2017 Número de páginas: XI, 536 p. 53 ilustraciones, 48 ilustraciones en color. ISBN/ISSN/DL: 978-3-319-55520-1 Nota general: Libro disponible en la plataforma SpringerLink. Descarga y lectura en formatos PDF, HTML y ePub. Descarga completa o por capítulos. Idioma : Inglés (eng) Palabras clave: Biomateriales Ácidos nucleicos Genética vegetal Agricultura Biotecnología Ácido nucleico Clasificación: 620.19 Resumen: Este libro presenta, en 26 capítulos, el status quo en la elaboración de perfiles epigenómicos. Se analiza cómo se puede inferir indirectamente la información funcional y se describen los nuevos enfoques que prometen respuestas funcionales, denominados colectivamente edición del epigenoma. Destaca los últimos avances importantes en nuestra comprensión de las funciones de la epigenómica vegetal y las nuevas tecnologías para el estudio de marcas y mecanismos epigenómicos en plantas. Los temas incluyen la deposición o eliminación de modificaciones de la cromatina y variantes de histonas, el papel de la epigenética en el desarrollo y la respuesta a señales ambientales, la variación natural y la ecología, así como aplicaciones de la epigenética en el mejoramiento de cultivos. Al analizar áreas que van desde la compleja regulación del estrés y la heterosis hasta los mecanismos precisos del ADN y las modificaciones de las histonas, presenta avances en nuestra comprensión de los fenómenos fenotípicos complejos. Nota de contenido: Chapter 1: Conservation, Divergence and Abundance of MiRNAs and Their Effect in Plants -- Chapter 2: The Role of MiRNAs in Auxin Signaling and Regulation During Plant Development -- Chapter 3: Growing Diversity of Plant MicroRNAs and MIR-Derived Small RNAs -- Chapter 4: An Evolutionary View of the Biogenesis and Function of Rice Small RNAs -- Chapter 5: Small RNAs: Master regulators of epigenetic silencing in plants -- Chapter 6: Small RNA biogenesis and degradation in plants -- Chapter 7: Plant Epigenetics: Non-Coding RNAs as Emerging Regulators -- Chapter 8: Genome-Wide Function Analysis of LincRNAs as MiRNA Targets or Decoys in Plant -- Chapter 9: Plant Noncoding RNAs and the New Paradigms -- Chapter 10: Epigenetic Regulation by Non-Coding RNAs in Plant Development -- Chapter 11: RNAi Suppressors: Biology and Mechanisms -- Chapter 12: Analysis of Nucleic Acids Methylation in Plants -- Chapter 13: DNA Methylation in Plants by MicroRNAs -- Chapter 14: DNA Methylation in Plants and its Implicationsin Development, Hybrid Vigor and Evolution -- Chapter 15: Dynamic DNA Methylation Patterns in Stress Response -- Chapter 16: Locus-specific DNA methylation analysis and applications to plants -- Chapter 17: Epigenetics in Plant Reproductive Development: An Overview from Flowers to Seeds -- Chapter 18: Epigenetic Regulation of Phase Transitions in Arabidopsis thaliana -- Chapter 19: Epigenetics in Plant-Pathogen Interactions -- Chapter 20: Epigenetic Reprogramming During Plant Reproduction -- Chapter 21: Rice Epigenomics: how does Epigenetic Manipulation of Crops Contribute to Agriculture? -- Chapter 22: Epigenetic Characterization of Satellite DNA in Sugar Beet (Beta vulgaris) -- Chapter 23: Universal and Lineage-specific Properties of Linker Histones and SWI/SNF-chromatin Remodeling Complexes in Plants -- Chapter 24: Abiotic Stress Induced Epigenetic Modifications in Plants: How Much do we Know? -- Chapter 25: Apple Latent Spherical Virus (ALSV) Vector as a Tool for Reverse Genetic Studies andNon-Transgenic Breeding of a Variety of Crops. Tipo de medio : Computadora Summary : This book presents, in 26 chapters, the status quo in epigenomic profiling. It discusses how functional information can be indirectly inferred and describes the new approaches that promise functional answers, collectively referred to as epigenome editing. It highlights the latest important advances in our understanding of the functions of plant epigenomics and new technologies for the study of epigenomic marks and mechanisms in plants. Topics include the deposition or removal of chromatin modifications and histone variants, the role of epigenetics in development and response to environmental signals, natural variation and ecology, as well as applications for epigenetics in crop improvement. Discussing areas ranging from the complex regulation of stress and heterosis to the precise mechanisms of DNA and histone modifications, it presents breakthroughs in our understanding of complex phenotypic phenomena. Enlace de acceso : https://link-springer-com.biblioproxy.umanizales.edu.co/referencework/10.1007/97 [...] Plant Epigenetics [documento electrónico] / Rajewsky, Nikolaus, ; Jurga, Stefan, ; Barciszewski, Jan, . - 1 ed. . - [s.l.] : Springer, 2017 . - XI, 536 p. 53 ilustraciones, 48 ilustraciones en color.
ISBN : 978-3-319-55520-1
Libro disponible en la plataforma SpringerLink. Descarga y lectura en formatos PDF, HTML y ePub. Descarga completa o por capítulos.
Idioma : Inglés (eng)
Palabras clave: Biomateriales Ácidos nucleicos Genética vegetal Agricultura Biotecnología Ácido nucleico Clasificación: 620.19 Resumen: Este libro presenta, en 26 capítulos, el status quo en la elaboración de perfiles epigenómicos. Se analiza cómo se puede inferir indirectamente la información funcional y se describen los nuevos enfoques que prometen respuestas funcionales, denominados colectivamente edición del epigenoma. Destaca los últimos avances importantes en nuestra comprensión de las funciones de la epigenómica vegetal y las nuevas tecnologías para el estudio de marcas y mecanismos epigenómicos en plantas. Los temas incluyen la deposición o eliminación de modificaciones de la cromatina y variantes de histonas, el papel de la epigenética en el desarrollo y la respuesta a señales ambientales, la variación natural y la ecología, así como aplicaciones de la epigenética en el mejoramiento de cultivos. Al analizar áreas que van desde la compleja regulación del estrés y la heterosis hasta los mecanismos precisos del ADN y las modificaciones de las histonas, presenta avances en nuestra comprensión de los fenómenos fenotípicos complejos. Nota de contenido: Chapter 1: Conservation, Divergence and Abundance of MiRNAs and Their Effect in Plants -- Chapter 2: The Role of MiRNAs in Auxin Signaling and Regulation During Plant Development -- Chapter 3: Growing Diversity of Plant MicroRNAs and MIR-Derived Small RNAs -- Chapter 4: An Evolutionary View of the Biogenesis and Function of Rice Small RNAs -- Chapter 5: Small RNAs: Master regulators of epigenetic silencing in plants -- Chapter 6: Small RNA biogenesis and degradation in plants -- Chapter 7: Plant Epigenetics: Non-Coding RNAs as Emerging Regulators -- Chapter 8: Genome-Wide Function Analysis of LincRNAs as MiRNA Targets or Decoys in Plant -- Chapter 9: Plant Noncoding RNAs and the New Paradigms -- Chapter 10: Epigenetic Regulation by Non-Coding RNAs in Plant Development -- Chapter 11: RNAi Suppressors: Biology and Mechanisms -- Chapter 12: Analysis of Nucleic Acids Methylation in Plants -- Chapter 13: DNA Methylation in Plants by MicroRNAs -- Chapter 14: DNA Methylation in Plants and its Implicationsin Development, Hybrid Vigor and Evolution -- Chapter 15: Dynamic DNA Methylation Patterns in Stress Response -- Chapter 16: Locus-specific DNA methylation analysis and applications to plants -- Chapter 17: Epigenetics in Plant Reproductive Development: An Overview from Flowers to Seeds -- Chapter 18: Epigenetic Regulation of Phase Transitions in Arabidopsis thaliana -- Chapter 19: Epigenetics in Plant-Pathogen Interactions -- Chapter 20: Epigenetic Reprogramming During Plant Reproduction -- Chapter 21: Rice Epigenomics: how does Epigenetic Manipulation of Crops Contribute to Agriculture? -- Chapter 22: Epigenetic Characterization of Satellite DNA in Sugar Beet (Beta vulgaris) -- Chapter 23: Universal and Lineage-specific Properties of Linker Histones and SWI/SNF-chromatin Remodeling Complexes in Plants -- Chapter 24: Abiotic Stress Induced Epigenetic Modifications in Plants: How Much do we Know? -- Chapter 25: Apple Latent Spherical Virus (ALSV) Vector as a Tool for Reverse Genetic Studies andNon-Transgenic Breeding of a Variety of Crops. Tipo de medio : Computadora Summary : This book presents, in 26 chapters, the status quo in epigenomic profiling. It discusses how functional information can be indirectly inferred and describes the new approaches that promise functional answers, collectively referred to as epigenome editing. It highlights the latest important advances in our understanding of the functions of plant epigenomics and new technologies for the study of epigenomic marks and mechanisms in plants. Topics include the deposition or removal of chromatin modifications and histone variants, the role of epigenetics in development and response to environmental signals, natural variation and ecology, as well as applications for epigenetics in crop improvement. Discussing areas ranging from the complex regulation of stress and heterosis to the precise mechanisms of DNA and histone modifications, it presents breakthroughs in our understanding of complex phenotypic phenomena. Enlace de acceso : https://link-springer-com.biblioproxy.umanizales.edu.co/referencework/10.1007/97 [...]
Título : Systems Biology Tipo de documento: documento electrónico Autores: Rajewsky, Nikolaus, ; Jurga, Stefan, ; Barciszewski, Jan, Mención de edición: 1 ed. Editorial: [s.l.] : Springer Fecha de publicación: 2018 Número de páginas: X, 401 p. 60 ilustraciones, 46 ilustraciones en color. ISBN/ISSN/DL: 978-3-319-92967-5 Nota general: Libro disponible en la plataforma SpringerLink. Descarga y lectura en formatos PDF, HTML y ePub. Descarga completa o por capítulos. Idioma : Inglés (eng) Palabras clave: Bioinformática Genética Médica Biología Biomateriales Ácidos nucleicos Biotecnología Biología Computacional y de Sistemas Investigación biomédica Ácido nucleico Clasificación: 570.285 Resumen: Muchos avances en dispositivos experimentales, software avanzado y métodos analíticos para el desarrollo de la biología de sistemas han ayudado a dar forma a la forma en que estudiamos el ADN, el ARN y las proteínas, a nivel genómico, transcripcional, traslacional y postraduccional. Este libro destaca los temas integrales que abarcan la biología de sistemas con enormes avances en el desarrollo de la secuenciación del genoma, métodos proteómicos y metabolómicos en el diseño y comprensión de sistemas biológicos. Los temas tratados en este libro incluyen los fundamentos del modelado de redes, circuitos y vías, sistemas espaciales y multicelulares, biología de sistemas basados en imágenes, evolución, ruido y toma de decisiones en células individuales, biología de sistemas de enfermedades e inmunología, y medicina personalizada. Se presta especial atención a la epigenómica, en particular a las condiciones ambientales que afectan el trasfondo genético. También se describe la amplitud de datos nuevos e interesantes para descubrir principios fundamentales y la aplicación directa de la epigenética en la agricultura. El capítulo "Descifrando el universo de las estructuras de ARN y las interacciones trans ARN-ARN de transcriptomas in vivo: desde protocolos experimentales hasta análisis computacionales" está disponible en acceso abierto bajo una licencia CC BY 4.0 a través de link.springer.com. Nota de contenido: Chapter 1: Systems Biology of Genome Structure and Dynamics -- Chapter 2: A Systems Perspective of Complex Diseases: from Reductionism to Integration -- Chapter 3: Systems Biology of Bacterial Immune Systems: Regulation of Restriction-Modification and CRISPR-Cas Systems -- Chapter 4: Systems Biology of RNA Binding Proteins in Amyotrophic Lateral Sclerosis -- Chapter 5: Systems Approaches to Map in vivo RNA-Protein Interactions in Arabidopsis thaliana -- Chapter 6: Systems-Level Analysis of Bacterial Regulatory Small RNA Networks -- Chapter 7: Epioncogenes in Cancer—Identification of Transcriptomic and Epigenomic Cooperation Networks by Multi-Omics Integration of RNA-Seq and ChIP-Seqdata -- Chapter 8: Coupling Large Scale –Omics Data for Deciphering Systems Complexity -- Chapter 9: Deciphering the Universe of RNA Structures and tTans RNA-RNA Interactions of Transcriptomes in vivo / from Experimental Protocols to Computational Analyses -- Chapter 10: Is Autogenous Post-Transcriptional Gene Regulation Common? -- Chapter 11: The Interplay of Non-Coding RNAs and X Chromosome Inactivation in Human Disease -- Chapter 12: Novel Insights of the Gene Translational Dynamic and Complex Revealed by Ribosome Profiling -- Chapter 13: Biophysical Analysis of MiRNA-Dependent Gene Regulation -- Chapter 14: Modeling and Analyzing the Flow of Molecular Machines in Gene Expression -- Chapter 15: Robust Approaches to Generating Reliable Predictive Models in Systems Biology -- Chapter 16: Hints from Information Theory for Analyzing Dynamic & High Dimensional Biological Data -- Chapter 17: Enhancing Metabolic Models with Genome-Scale Experimental Data -- Chapter 18: An Integrative MuSiCO Algorithm: from the Patient-Specific Transcriptional Profiles to Novel Checkpoints in Disease Pathobiology -- Chapter 19: Nanocellulose: a New Multifunctional Tool for RNA System Biology Research. Tipo de medio : Computadora Summary : Many breakthroughs in experimental devices, advanced software, as well as analytical methods for systems biology development have helped shape the way we study DNA, RNA and proteins, on the genomic, transcriptional, translational and posttranslational level. This book highlights the comprehensive topics that encompass systems biology with enormous progress in the development of genome sequencing, proteomic and metabolomic methods in designing and understanding biological systems. Topics covered in this book include fundamentals of modelling networks, circuits and pathways, spatial and multi cellular systems, image-driven systems biology, evolution, noise and decision-making in single cells, systems biology of disease and immunology, and personalized medicine. Special attention is paid to epigenomics, in particular environmental conditions that impact genetic background. The breadth of exciting new data towards discovering fundamental principles and direct applicationof epigenetics in agriculture is also described. The chapter "Deciphering the Universe of RNA Structures and Trans RNA-RNA Interactions of Transcriptomes in vivo - from Experimental Protocols to Computational Analyses" is available open access under a CC BY 4.0 license via link.springer.com. Enlace de acceso : https://link-springer-com.biblioproxy.umanizales.edu.co/referencework/10.1007/97 [...] Systems Biology [documento electrónico] / Rajewsky, Nikolaus, ; Jurga, Stefan, ; Barciszewski, Jan, . - 1 ed. . - [s.l.] : Springer, 2018 . - X, 401 p. 60 ilustraciones, 46 ilustraciones en color.
ISBN : 978-3-319-92967-5
Libro disponible en la plataforma SpringerLink. Descarga y lectura en formatos PDF, HTML y ePub. Descarga completa o por capítulos.
Idioma : Inglés (eng)
Palabras clave: Bioinformática Genética Médica Biología Biomateriales Ácidos nucleicos Biotecnología Biología Computacional y de Sistemas Investigación biomédica Ácido nucleico Clasificación: 570.285 Resumen: Muchos avances en dispositivos experimentales, software avanzado y métodos analíticos para el desarrollo de la biología de sistemas han ayudado a dar forma a la forma en que estudiamos el ADN, el ARN y las proteínas, a nivel genómico, transcripcional, traslacional y postraduccional. Este libro destaca los temas integrales que abarcan la biología de sistemas con enormes avances en el desarrollo de la secuenciación del genoma, métodos proteómicos y metabolómicos en el diseño y comprensión de sistemas biológicos. Los temas tratados en este libro incluyen los fundamentos del modelado de redes, circuitos y vías, sistemas espaciales y multicelulares, biología de sistemas basados en imágenes, evolución, ruido y toma de decisiones en células individuales, biología de sistemas de enfermedades e inmunología, y medicina personalizada. Se presta especial atención a la epigenómica, en particular a las condiciones ambientales que afectan el trasfondo genético. También se describe la amplitud de datos nuevos e interesantes para descubrir principios fundamentales y la aplicación directa de la epigenética en la agricultura. El capítulo "Descifrando el universo de las estructuras de ARN y las interacciones trans ARN-ARN de transcriptomas in vivo: desde protocolos experimentales hasta análisis computacionales" está disponible en acceso abierto bajo una licencia CC BY 4.0 a través de link.springer.com. Nota de contenido: Chapter 1: Systems Biology of Genome Structure and Dynamics -- Chapter 2: A Systems Perspective of Complex Diseases: from Reductionism to Integration -- Chapter 3: Systems Biology of Bacterial Immune Systems: Regulation of Restriction-Modification and CRISPR-Cas Systems -- Chapter 4: Systems Biology of RNA Binding Proteins in Amyotrophic Lateral Sclerosis -- Chapter 5: Systems Approaches to Map in vivo RNA-Protein Interactions in Arabidopsis thaliana -- Chapter 6: Systems-Level Analysis of Bacterial Regulatory Small RNA Networks -- Chapter 7: Epioncogenes in Cancer—Identification of Transcriptomic and Epigenomic Cooperation Networks by Multi-Omics Integration of RNA-Seq and ChIP-Seqdata -- Chapter 8: Coupling Large Scale –Omics Data for Deciphering Systems Complexity -- Chapter 9: Deciphering the Universe of RNA Structures and tTans RNA-RNA Interactions of Transcriptomes in vivo / from Experimental Protocols to Computational Analyses -- Chapter 10: Is Autogenous Post-Transcriptional Gene Regulation Common? -- Chapter 11: The Interplay of Non-Coding RNAs and X Chromosome Inactivation in Human Disease -- Chapter 12: Novel Insights of the Gene Translational Dynamic and Complex Revealed by Ribosome Profiling -- Chapter 13: Biophysical Analysis of MiRNA-Dependent Gene Regulation -- Chapter 14: Modeling and Analyzing the Flow of Molecular Machines in Gene Expression -- Chapter 15: Robust Approaches to Generating Reliable Predictive Models in Systems Biology -- Chapter 16: Hints from Information Theory for Analyzing Dynamic & High Dimensional Biological Data -- Chapter 17: Enhancing Metabolic Models with Genome-Scale Experimental Data -- Chapter 18: An Integrative MuSiCO Algorithm: from the Patient-Specific Transcriptional Profiles to Novel Checkpoints in Disease Pathobiology -- Chapter 19: Nanocellulose: a New Multifunctional Tool for RNA System Biology Research. Tipo de medio : Computadora Summary : Many breakthroughs in experimental devices, advanced software, as well as analytical methods for systems biology development have helped shape the way we study DNA, RNA and proteins, on the genomic, transcriptional, translational and posttranslational level. This book highlights the comprehensive topics that encompass systems biology with enormous progress in the development of genome sequencing, proteomic and metabolomic methods in designing and understanding biological systems. Topics covered in this book include fundamentals of modelling networks, circuits and pathways, spatial and multi cellular systems, image-driven systems biology, evolution, noise and decision-making in single cells, systems biology of disease and immunology, and personalized medicine. Special attention is paid to epigenomics, in particular environmental conditions that impact genetic background. The breadth of exciting new data towards discovering fundamental principles and direct applicationof epigenetics in agriculture is also described. The chapter "Deciphering the Universe of RNA Structures and Trans RNA-RNA Interactions of Transcriptomes in vivo - from Experimental Protocols to Computational Analyses" is available open access under a CC BY 4.0 license via link.springer.com. Enlace de acceso : https://link-springer-com.biblioproxy.umanizales.edu.co/referencework/10.1007/97 [...]
Título : The Chemical Biology of Long Noncoding RNAs Tipo de documento: documento electrónico Autores: Jurga, Stefan, ; Barciszewski, Jan, Mención de edición: 1 ed. Editorial: [s.l.] : Springer Fecha de publicación: 2020 Número de páginas: X, 545 p. 49 ilustraciones, 45 ilustraciones en color. ISBN/ISSN/DL: 978-3-030-44743-4 Nota general: Libro disponible en la plataforma SpringerLink. Descarga y lectura en formatos PDF, HTML y ePub. Descarga completa o por capítulos. Idioma : Inglés (eng) Palabras clave: Genética Médica Biomateriales Ácidos nucleicos Biotecnología Ácido nucleico Clasificación: 616.042 Resumen: Este libro ofrece una descripción completa y detallada de varios aspectos de los ARN largos no codificantes. Se analiza su importancia emergente en la medicina molecular, desde los cánceres humanos hasta las enfermedades cardiovasculares y metabólicas. Los estudios transcriptómicos han demostrado que la mayoría de los genomas que se encuentran en organismos complejos se expresan en patrones altamente dinámicos y específicos de cada célula, produciendo grandes cantidades de ARN largos no codificantes de proteínas (lncRNA) intergénicos, antisentido e intrónicos. Se han identificado miles de lncRNA y, a diferencia del ARNm, no tienen capacidad de codificación de proteínas. Un gran repertorio de ncRNA, transcritos activamente del genoma de los mamíferos, controla diversos procesos celulares, tanto en términos de desarrollo como de enfermedades, a través de una variedad de mecanismos reguladores de genes. Los IncRNA han surgido como un nuevo paradigma en la regulación epigenética del genoma. Dado su alcance, el libro será de particular interés para los biólogos moleculares, químicos, celulares y del desarrollo, así como para los especialistas en medicina traslacional involucrados en la investigación orientada a las enfermedades. También ofrece un recurso valioso para los expertos in silico que buscan una comprensión más profunda de la expresión y función del lncRNA mediante el análisis computacional de los datos de NGS. Nota de contenido: Long Non-Coding RNAs Diversity in Form and Function - from Microbes to Humans -- Evolving Roles of Long Noncoding RNAs -- Biogenesis and Function of the Noncoding Isoform-Type LncRNAs -- Long Non-Coding RNAs in a Single Cell Type: Function and Subcellular Localization -- Long Non-Coding RNAs as Scaffolds for Multiprotein Signalling Complexes -- Landscape of Long Non-Coding RNA Genes, Pseudogenes and Protein Genes in Segmental Duplications in the Critical Human Chromosomal Region 22q11.2 -- Long Non-Coding RNAs and Cancer Cells' Drug Resistance: an Unexpected Connection -- Long Noncoding RNAs as Drivers of Acquired Chemoresistance in Hepatocellular Carcinoma -- Single Cell Analysis May Shed new Lights on the Role of LncRNAs in Chemo-Resistance in Gastrointestinal Cancers -- LncRNAs in the Development, Progression, and Therapy Resistance of Hormone-Dependent Cancer -- Tumorigenesis-Related Long Non-Coding RNAs and their Targeting as Therapeutic Approach in Cancer -- Long Non-Coding RNAs inNon-Small Cell Lung Cancer: State of the Art -- Long Non-Coding RNAs in Cardiovascular Diseases -- Long Non-Coding RNAs in Cardiovascular Development and Diseases.-Long Noncoding RNAs as Players in Breast Tumorigenesis -- Drosophila Models to Study Long Non-Coding RNAs Related to Neurological Disorders -- Regulatory Roles of Long Non-Coding RNAs in Skeletal Muscle Differentiation, Regeneration, and Disorders -- Long Noncoding RNAs in Substance Use Disorders -- The Multifaceted Roles of LncRNAs in Diabetic Complications: a Promising, yet Perplexing Paradigm -- Long Non-Coding RNAs in Diabetes and β-cell Regulation. Tipo de medio : Computadora Summary : This book offers a comprehensive and detailed overview of various aspects of long non-coding RNAs. It discusses their emerging significance in molecular medicine, ranging from human cancers to cardiovascular and metabolic diseases. Transcriptomic studies have demonstrated that the majority of genomes found in complex organisms are expressed in highly dynamic and cell-specific patterns, producing huge numbers of intergenic, antisense and intronic long non-protein-coding RNAs (lncRNAs). Thousands of lncRNAs have been identified, and unlike mRNA, they have no protein-coding capacity. A large repertoire of ncRNAs, actively transcribed from the mammalian genome, control diverse cellular processes, both in terms of development and diseases, through a variety of gene regulatory mechanisms. IncRNAs have emerged as a new paradigm in epigenetic regulation of the genome. Given its scope, the book will be of particular interest to molecular, chemical, cell and developmental biologists,as well as specialists in translational medicine involved in disease-oriented research. It also offers a valuable resource for in silico experts seeking a deeper understanding of lncRNA expression and function through computational analysis of the NGS data. Enlace de acceso : https://link-springer-com.biblioproxy.umanizales.edu.co/referencework/10.1007/97 [...] The Chemical Biology of Long Noncoding RNAs [documento electrónico] / Jurga, Stefan, ; Barciszewski, Jan, . - 1 ed. . - [s.l.] : Springer, 2020 . - X, 545 p. 49 ilustraciones, 45 ilustraciones en color.
ISBN : 978-3-030-44743-4
Libro disponible en la plataforma SpringerLink. Descarga y lectura en formatos PDF, HTML y ePub. Descarga completa o por capítulos.
Idioma : Inglés (eng)
Palabras clave: Genética Médica Biomateriales Ácidos nucleicos Biotecnología Ácido nucleico Clasificación: 616.042 Resumen: Este libro ofrece una descripción completa y detallada de varios aspectos de los ARN largos no codificantes. Se analiza su importancia emergente en la medicina molecular, desde los cánceres humanos hasta las enfermedades cardiovasculares y metabólicas. Los estudios transcriptómicos han demostrado que la mayoría de los genomas que se encuentran en organismos complejos se expresan en patrones altamente dinámicos y específicos de cada célula, produciendo grandes cantidades de ARN largos no codificantes de proteínas (lncRNA) intergénicos, antisentido e intrónicos. Se han identificado miles de lncRNA y, a diferencia del ARNm, no tienen capacidad de codificación de proteínas. Un gran repertorio de ncRNA, transcritos activamente del genoma de los mamíferos, controla diversos procesos celulares, tanto en términos de desarrollo como de enfermedades, a través de una variedad de mecanismos reguladores de genes. Los IncRNA han surgido como un nuevo paradigma en la regulación epigenética del genoma. Dado su alcance, el libro será de particular interés para los biólogos moleculares, químicos, celulares y del desarrollo, así como para los especialistas en medicina traslacional involucrados en la investigación orientada a las enfermedades. También ofrece un recurso valioso para los expertos in silico que buscan una comprensión más profunda de la expresión y función del lncRNA mediante el análisis computacional de los datos de NGS. Nota de contenido: Long Non-Coding RNAs Diversity in Form and Function - from Microbes to Humans -- Evolving Roles of Long Noncoding RNAs -- Biogenesis and Function of the Noncoding Isoform-Type LncRNAs -- Long Non-Coding RNAs in a Single Cell Type: Function and Subcellular Localization -- Long Non-Coding RNAs as Scaffolds for Multiprotein Signalling Complexes -- Landscape of Long Non-Coding RNA Genes, Pseudogenes and Protein Genes in Segmental Duplications in the Critical Human Chromosomal Region 22q11.2 -- Long Non-Coding RNAs and Cancer Cells' Drug Resistance: an Unexpected Connection -- Long Noncoding RNAs as Drivers of Acquired Chemoresistance in Hepatocellular Carcinoma -- Single Cell Analysis May Shed new Lights on the Role of LncRNAs in Chemo-Resistance in Gastrointestinal Cancers -- LncRNAs in the Development, Progression, and Therapy Resistance of Hormone-Dependent Cancer -- Tumorigenesis-Related Long Non-Coding RNAs and their Targeting as Therapeutic Approach in Cancer -- Long Non-Coding RNAs inNon-Small Cell Lung Cancer: State of the Art -- Long Non-Coding RNAs in Cardiovascular Diseases -- Long Non-Coding RNAs in Cardiovascular Development and Diseases.-Long Noncoding RNAs as Players in Breast Tumorigenesis -- Drosophila Models to Study Long Non-Coding RNAs Related to Neurological Disorders -- Regulatory Roles of Long Non-Coding RNAs in Skeletal Muscle Differentiation, Regeneration, and Disorders -- Long Noncoding RNAs in Substance Use Disorders -- The Multifaceted Roles of LncRNAs in Diabetic Complications: a Promising, yet Perplexing Paradigm -- Long Non-Coding RNAs in Diabetes and β-cell Regulation. Tipo de medio : Computadora Summary : This book offers a comprehensive and detailed overview of various aspects of long non-coding RNAs. It discusses their emerging significance in molecular medicine, ranging from human cancers to cardiovascular and metabolic diseases. Transcriptomic studies have demonstrated that the majority of genomes found in complex organisms are expressed in highly dynamic and cell-specific patterns, producing huge numbers of intergenic, antisense and intronic long non-protein-coding RNAs (lncRNAs). Thousands of lncRNAs have been identified, and unlike mRNA, they have no protein-coding capacity. A large repertoire of ncRNAs, actively transcribed from the mammalian genome, control diverse cellular processes, both in terms of development and diseases, through a variety of gene regulatory mechanisms. IncRNAs have emerged as a new paradigm in epigenetic regulation of the genome. Given its scope, the book will be of particular interest to molecular, chemical, cell and developmental biologists,as well as specialists in translational medicine involved in disease-oriented research. It also offers a valuable resource for in silico experts seeking a deeper understanding of lncRNA expression and function through computational analysis of the NGS data. Enlace de acceso : https://link-springer-com.biblioproxy.umanizales.edu.co/referencework/10.1007/97 [...]
Título : The DNA, RNA, and Histone Methylomes Tipo de documento: documento electrónico Autores: Jurga, Stefan, ; Barciszewski, Jan, Mención de edición: 1 ed. Editorial: [s.l.] : Springer Fecha de publicación: 2019 Número de páginas: XI, 624 p. 78 ilustraciones, 57 ilustraciones en color. ISBN/ISSN/DL: 978-3-030-14792-1 Nota general: Libro disponible en la plataforma SpringerLink. Descarga y lectura en formatos PDF, HTML y ePub. Descarga completa o por capítulos. Idioma : Inglés (eng) Palabras clave: Genética Médica Biomateriales Ácidos nucleicos Biotecnología Citología Ácido nucleico Bioingeniería Química Biología Celular Clasificación: 616.042 Resumen: Este libro analiza los mecanismos químicos, reguladores y fisiológicos de las metiltransferasas de las proteínas arginina y lisina, así como las metilaciones de ácidos nucleicos y las enzimas metilantes. La metilación de proteínas y ácidos nucleicos desempeña papeles clave y diversos en la señalización celular y la regulación de las funciones celulares macromoleculares. Las metiltransferasas de las proteínas arginina y lisina son las enzimas predominantes que catalizan la metilación de sustratos proteicos dependiente de S-adenosilmetionina (SAM). Estas enzimas catalizan una sustitución nucleofílica de un grupo metilo a un átomo de nitrógeno (N) de la cadena lateral de arginina o lisina. Las células también tienen metiltransferasas de proteínas adicionales, que se dirigen a otros aminoácidos en las cadenas laterales peptidil o en los extremos N y C, como el glutamato, la glutamina y la histidina. Todas estas metiltransferasas de proteínas utilizan un mecanismo similar. Por el contrario, los ácidos nucleicos (ADN y ARN) son sustratos para las enzimas metilantes, que emplean diversos mecanismos químicos para metilar nucleósidos en átomos de nitrógeno (N), oxígeno (O) y carbono (C). Este libro ilustra cómo, gracias a su capacidad para ampliar su repertorio de funciones a los sustratos modificados, los procesos de metilación de proteínas y ácidos nucleicos desempeñan un papel clave en las células. Nota de contenido: Chapter 1. Establishment, Erasure and Synthetic Reprogramming of DNA Methylation in Mammalian Cells -- Chapter 2. Origin and Mechanisms of DNA Methylation Dynamics in Cancers -- Chapter 3. CpG Islands Methylation Alterations in Cancer: Functionally Intriguing Security Locks, Useful Early Tumor Biomarkers -- Chapter 4. Histone and DNA Methylome in Neurodegenerative, Neuropsychiatric and Neurodevelopmental Disorders -- Chapter 5. DNA Methylation in Neuronal Development and Disease -- Chapter 6. Functional Implications of Dynamic DNA Methylation for the Developing, Aging and Diseased Brain -- Chapter 7. The Methylome of Bipolar Disorder: Evidence from Human and Animal Studies -- Chapter 8. DNA Methylation in Multiple Sclerosis -- Chapter 9. Early Life Stress and DNA Methylation -- Chapter 10. Regulation of 5-hydroxymethylcytosine Distribution by the TET Enzymes -- Chapter 11. Epigenetic Alterations: The Relation Between Occupational Exposure and Biological Effects in Humans -- Chapter 12. DNA Methylation: Biological Implications and Modulation of its Aberrant Dysregulation -- Chapter 13. Functions and Dynamics of Methylation in Eukaryotic mRNA -- Chapter 14. The Role of mRNA m6A in Regulation of Gene Expression -- Chapter 15. G9a and G9a-like Histone Methyltransferases and Their Effect on Cell Phenotype, Embryonic Development, and Human Disease -- Chapter 16. Biomolecular Recognition of Methylated Histones -- Chapter 17. The Role of Protein Lysine Methylation in the Regulation of Protein Function - Looking Beyond the Histone Code -- Chapter 18. Secondary Structures of Histone H3 Proteins with Unmethylated and Methylated Lysine-4 and -9 Resiudes; Characterization Using Circular Dichroism Spectroscopy -- Chapter 19. Asymmetric Dimethylation on Arginine (ADMA) of Histones in Development, Differentiation and Disease -- Chapter 20. A Switch for Transcriptional Activation and Repression: Histone Arginine Methylation -- Chapter 21. Aberrant Epigenomic Regulatory Networks in Multiple Myeloma and Strategies for their Targeted Reversal -- Chapter 22. Metabolic Deregulations Affecting Chromatin Architecture: One-carbon Metabolism and Krebs Cycle Impact Histone Methylation -- Chapter 23. Histone Methylome of the Human Parasite Schistosoma Mansoni. Tipo de medio : Computadora Summary : This book reviews the chemical, regulatory, and physiological mechanisms of protein arginine and lysine methyltransferases, as well as nucleic acid methylations and methylating enzymes. Protein and nucleic acid methylation play key and diverse roles in cellular signalling and regulating macromolecular cell functions. Protein arginine and lysine methyltransferases are the predominant enzymes that catalyse S-adenosylmethionine (SAM)-dependent methylation of protein substrates. These enzymes catalyse a nucleophilic substitution of a methyl group to an arginine or lysine side chain nitrogen (N) atom. Cells also have additional protein methyltransferases, which target other amino acids in peptidyl side chains or N-termini and C-termini, such as glutamate, glutamine, and histidine. All these protein methyltransferases use a similar mechanism. In contrast, nucleic acids (DNA and RNA) are substrates for methylating enzymes, which employ various chemical mechanisms to methylate nucleosides at nitrogen (N), oxygen (O), and carbon (C) atoms. This book illustrates how, thanks to there ability to expand their repertoire of functions to the modified substrates, protein and nucleic acid methylation processes play a key role in cells. Enlace de acceso : https://link-springer-com.biblioproxy.umanizales.edu.co/referencework/10.1007/97 [...] The DNA, RNA, and Histone Methylomes [documento electrónico] / Jurga, Stefan, ; Barciszewski, Jan, . - 1 ed. . - [s.l.] : Springer, 2019 . - XI, 624 p. 78 ilustraciones, 57 ilustraciones en color.
ISBN : 978-3-030-14792-1
Libro disponible en la plataforma SpringerLink. Descarga y lectura en formatos PDF, HTML y ePub. Descarga completa o por capítulos.
Idioma : Inglés (eng)
Palabras clave: Genética Médica Biomateriales Ácidos nucleicos Biotecnología Citología Ácido nucleico Bioingeniería Química Biología Celular Clasificación: 616.042 Resumen: Este libro analiza los mecanismos químicos, reguladores y fisiológicos de las metiltransferasas de las proteínas arginina y lisina, así como las metilaciones de ácidos nucleicos y las enzimas metilantes. La metilación de proteínas y ácidos nucleicos desempeña papeles clave y diversos en la señalización celular y la regulación de las funciones celulares macromoleculares. Las metiltransferasas de las proteínas arginina y lisina son las enzimas predominantes que catalizan la metilación de sustratos proteicos dependiente de S-adenosilmetionina (SAM). Estas enzimas catalizan una sustitución nucleofílica de un grupo metilo a un átomo de nitrógeno (N) de la cadena lateral de arginina o lisina. Las células también tienen metiltransferasas de proteínas adicionales, que se dirigen a otros aminoácidos en las cadenas laterales peptidil o en los extremos N y C, como el glutamato, la glutamina y la histidina. Todas estas metiltransferasas de proteínas utilizan un mecanismo similar. Por el contrario, los ácidos nucleicos (ADN y ARN) son sustratos para las enzimas metilantes, que emplean diversos mecanismos químicos para metilar nucleósidos en átomos de nitrógeno (N), oxígeno (O) y carbono (C). Este libro ilustra cómo, gracias a su capacidad para ampliar su repertorio de funciones a los sustratos modificados, los procesos de metilación de proteínas y ácidos nucleicos desempeñan un papel clave en las células. Nota de contenido: Chapter 1. Establishment, Erasure and Synthetic Reprogramming of DNA Methylation in Mammalian Cells -- Chapter 2. Origin and Mechanisms of DNA Methylation Dynamics in Cancers -- Chapter 3. CpG Islands Methylation Alterations in Cancer: Functionally Intriguing Security Locks, Useful Early Tumor Biomarkers -- Chapter 4. Histone and DNA Methylome in Neurodegenerative, Neuropsychiatric and Neurodevelopmental Disorders -- Chapter 5. DNA Methylation in Neuronal Development and Disease -- Chapter 6. Functional Implications of Dynamic DNA Methylation for the Developing, Aging and Diseased Brain -- Chapter 7. The Methylome of Bipolar Disorder: Evidence from Human and Animal Studies -- Chapter 8. DNA Methylation in Multiple Sclerosis -- Chapter 9. Early Life Stress and DNA Methylation -- Chapter 10. Regulation of 5-hydroxymethylcytosine Distribution by the TET Enzymes -- Chapter 11. Epigenetic Alterations: The Relation Between Occupational Exposure and Biological Effects in Humans -- Chapter 12. DNA Methylation: Biological Implications and Modulation of its Aberrant Dysregulation -- Chapter 13. Functions and Dynamics of Methylation in Eukaryotic mRNA -- Chapter 14. The Role of mRNA m6A in Regulation of Gene Expression -- Chapter 15. G9a and G9a-like Histone Methyltransferases and Their Effect on Cell Phenotype, Embryonic Development, and Human Disease -- Chapter 16. Biomolecular Recognition of Methylated Histones -- Chapter 17. The Role of Protein Lysine Methylation in the Regulation of Protein Function - Looking Beyond the Histone Code -- Chapter 18. Secondary Structures of Histone H3 Proteins with Unmethylated and Methylated Lysine-4 and -9 Resiudes; Characterization Using Circular Dichroism Spectroscopy -- Chapter 19. Asymmetric Dimethylation on Arginine (ADMA) of Histones in Development, Differentiation and Disease -- Chapter 20. A Switch for Transcriptional Activation and Repression: Histone Arginine Methylation -- Chapter 21. Aberrant Epigenomic Regulatory Networks in Multiple Myeloma and Strategies for their Targeted Reversal -- Chapter 22. Metabolic Deregulations Affecting Chromatin Architecture: One-carbon Metabolism and Krebs Cycle Impact Histone Methylation -- Chapter 23. Histone Methylome of the Human Parasite Schistosoma Mansoni. Tipo de medio : Computadora Summary : This book reviews the chemical, regulatory, and physiological mechanisms of protein arginine and lysine methyltransferases, as well as nucleic acid methylations and methylating enzymes. Protein and nucleic acid methylation play key and diverse roles in cellular signalling and regulating macromolecular cell functions. Protein arginine and lysine methyltransferases are the predominant enzymes that catalyse S-adenosylmethionine (SAM)-dependent methylation of protein substrates. These enzymes catalyse a nucleophilic substitution of a methyl group to an arginine or lysine side chain nitrogen (N) atom. Cells also have additional protein methyltransferases, which target other amino acids in peptidyl side chains or N-termini and C-termini, such as glutamate, glutamine, and histidine. All these protein methyltransferases use a similar mechanism. In contrast, nucleic acids (DNA and RNA) are substrates for methylating enzymes, which employ various chemical mechanisms to methylate nucleosides at nitrogen (N), oxygen (O), and carbon (C) atoms. This book illustrates how, thanks to there ability to expand their repertoire of functions to the modified substrates, protein and nucleic acid methylation processes play a key role in cells. Enlace de acceso : https://link-springer-com.biblioproxy.umanizales.edu.co/referencework/10.1007/97 [...]
