| Título : |
Epitranscriptomics |
| Tipo de documento: |
documento electrónico |
| Autores: |
Jurga, Stefan, ; Barciszewski, Jan, |
| Mención de edición: |
1 ed. |
| Editorial: |
[s.l.] : Springer |
| Fecha de publicación: |
2021 |
| Número de páginas: |
X, 632 p. 90 ilustraciones, 84 ilustraciones en color. |
| ISBN/ISSN/DL: |
978-3-030-71612-7 |
| Nota general: |
Libro disponible en la plataforma SpringerLink. Descarga y lectura en formatos PDF, HTML y ePub. Descarga completa o por capítulos. |
| Idioma : |
Inglés (eng) |
| Palabras clave: |
Epigenética ARN Bioquímica Bioinformática Metabolismo del ARN Química biológica |
| Clasificación: |
572.865 |
| Resumen: |
Este libro analiza un campo novedoso y apasionante de la biología celular y molecular llamado epitranscriptómica, que se centra en los cambios en las células de un organismo resultantes de la modificación postranscripcional del ARN celular. Las proteínas de unión a ARN (RBP) desempeñan un papel crucial en estas modificaciones postranscripcionales y también apoyan varios procesos celulares necesarios para mantener la homeostasis del ARN. Explorar los mecanismos subyacentes a las modificaciones del ARN y la función de la RBP es un área emergente de la investigación biomédica, que lleva el estudio de la regulación genética un paso más allá de la epigenética. Este libro revela que la molécula de ARN no es sólo una molécula portadora de información con algunas estructuras secundarias. En consecuencia, un aspecto importante es cómo se modifica, regula, empaqueta y controla el ARN. Los principales expertos abordan preguntas como dónde se ubican en el genoma las más de 170 modificaciones postranscripcionales distintas del ARN, qué porcentaje de ARNm y ARN no codificantes incluyen estas modificaciones y cómo una modificación del ARN afecta la biología de una persona. Para concluir, el libro revisa el papel de las modificaciones del ARN y las RBP en una variedad de enfermedades y su patogénesis. Este libro, que aborda algunos de los desafíos más interesantes de la epitranscriptómica, proporciona un recurso valioso y atractivo para los investigadores del mundo académico y de la industria que estudian los fenómenos de la modificación del ARN. |
| Nota de contenido: |
Epitranscriptomic Modifications and How to Find them -- Epitranscriptomic Signature in Neural Development and Disease -- The Emerging Neuroepitranscriptome -- Epitranscriptomics and Diseases -- Epitranscriptomic Marks and Systems Involved in Gene Regulation, Development and Disease -- Experimental Approaches and Computational Workflows for Systematic Mapping and Functional Interpretation of RNA Modifications -- RNA Modifications: The Mediator Between Cellular Stresses and Biological Effects -- Computational Prediction and Experimental Validation of Specific Modified RNA Sites -- Regulation of RNA Stability Utilizing RNA Modification -- Dynamic RNA Modification Upon Extracellular Stimulus -- RNA Methylation in Cancer -- Regulation of RNA Methylation yy TET Enzymes -- RNA N6-Methyladenosine and G-Quadruplex Structures in Bacteria -- RNA N6-Methyladenosine Chemical Modification as a Therapeutic Target -- Cap-Adjacent m6Am and its Effects On mRNA -- N6-Methyladenosine in The Heart -- The m6a RNA Methylation Regulates Oncogenic Signaling Pathways Driving Cell Transformation and Carcinogenesis -- Psivar: A Database of Functional Variants Involved in Pseudouridylation (Ψ) with Implications for Disease Pathogenesis -- C-to-U RNA Editing by Mammalian APOBEC Enzymes -- The Powerful Mechanism of RNA Editing and its Therapeutic Potentials -- Noncanonical Caps in RNA -- Mass Spectrometry-Based Methods for Characterization of Hypomodifications in tRNA -- Dynamic mRNA Modifications in Plants -- The Mammalian Mitochondrial Epitranscriptome -- Epitranscriptomics Modifications of Micrornas: Classes, Detection, Impact on their Functionality and Next Frontiers -- "Look Before You Leap" when Editing the Introns, or the Secrets Behind the Intronic Post-Transcriptional Modification -- Functional Links Between the Internal N6-Methyl Adenosine Modifications in mRNAs and Human Diseases -- RNA Modifications in Neurodevelopment and Neurodegenerations -- Conventional and Advanced Techniques for Methyl-6-Adenosine Modification Mapping in Transcripts -- Mechanisms and Therapeutic Applications of RNA-Guided RNA Pseudouridylation -- Epitranscriptomic Modifications in lnRNA and miRNA in Cancer and Other Diseases -- RNA m6A and Adipogenesis. |
| Tipo de medio : |
Computadora |
| Summary : |
This book reviews a novel and exciting field of cellular and molecular biology called epitranscriptomics, which focuses on changes in an organism's cells resulting from the posttranscriptional modification of cellular RNA. RNA-binding proteins (RBPs) play a crucial role in these posttranscriptional modifications and also support several cellular processes necessary for maintaining RNA homeostasis. Exploring the mechanisms underlying RNA modifications and RBP function is an emerging area of biomedical research, taking the study of gene regulation a step beyond epigenetics. This book reveals that the RNA molecule is not just an information-carrying molecule with some secondary structures. Accordingly, how RNA is modified, regulated, packaged, and controlled is an important aspect. Leading experts address questions such as where the over 170 distinct posttranscriptional RNA modifications are located on the genome, what percentage of mRNAs and noncoding RNAs these modifications include, and how an RNA modification impacts a person's biology. In closing, the book reviews the role of RNA modifications and RBPs in a variety of diseases and their pathogenesis. Addressing some of the most exciting challenges in epitranscriptomics, this book provides a valuable and engaging resource for researchers in academia and industry studying the phenomena of RNA modification. |
| Enlace de acceso : |
https://link-springer-com.biblioproxy.umanizales.edu.co/referencework/10.1007/97 [...] |
Epitranscriptomics [documento electrónico] / Jurga, Stefan, ; Barciszewski, Jan, . - 1 ed. . - [s.l.] : Springer, 2021 . - X, 632 p. 90 ilustraciones, 84 ilustraciones en color. ISBN : 978-3-030-71612-7 Libro disponible en la plataforma SpringerLink. Descarga y lectura en formatos PDF, HTML y ePub. Descarga completa o por capítulos. Idioma : Inglés ( eng)
| Palabras clave: |
Epigenética ARN Bioquímica Bioinformática Metabolismo del ARN Química biológica |
| Clasificación: |
572.865 |
| Resumen: |
Este libro analiza un campo novedoso y apasionante de la biología celular y molecular llamado epitranscriptómica, que se centra en los cambios en las células de un organismo resultantes de la modificación postranscripcional del ARN celular. Las proteínas de unión a ARN (RBP) desempeñan un papel crucial en estas modificaciones postranscripcionales y también apoyan varios procesos celulares necesarios para mantener la homeostasis del ARN. Explorar los mecanismos subyacentes a las modificaciones del ARN y la función de la RBP es un área emergente de la investigación biomédica, que lleva el estudio de la regulación genética un paso más allá de la epigenética. Este libro revela que la molécula de ARN no es sólo una molécula portadora de información con algunas estructuras secundarias. En consecuencia, un aspecto importante es cómo se modifica, regula, empaqueta y controla el ARN. Los principales expertos abordan preguntas como dónde se ubican en el genoma las más de 170 modificaciones postranscripcionales distintas del ARN, qué porcentaje de ARNm y ARN no codificantes incluyen estas modificaciones y cómo una modificación del ARN afecta la biología de una persona. Para concluir, el libro revisa el papel de las modificaciones del ARN y las RBP en una variedad de enfermedades y su patogénesis. Este libro, que aborda algunos de los desafíos más interesantes de la epitranscriptómica, proporciona un recurso valioso y atractivo para los investigadores del mundo académico y de la industria que estudian los fenómenos de la modificación del ARN. |
| Nota de contenido: |
Epitranscriptomic Modifications and How to Find them -- Epitranscriptomic Signature in Neural Development and Disease -- The Emerging Neuroepitranscriptome -- Epitranscriptomics and Diseases -- Epitranscriptomic Marks and Systems Involved in Gene Regulation, Development and Disease -- Experimental Approaches and Computational Workflows for Systematic Mapping and Functional Interpretation of RNA Modifications -- RNA Modifications: The Mediator Between Cellular Stresses and Biological Effects -- Computational Prediction and Experimental Validation of Specific Modified RNA Sites -- Regulation of RNA Stability Utilizing RNA Modification -- Dynamic RNA Modification Upon Extracellular Stimulus -- RNA Methylation in Cancer -- Regulation of RNA Methylation yy TET Enzymes -- RNA N6-Methyladenosine and G-Quadruplex Structures in Bacteria -- RNA N6-Methyladenosine Chemical Modification as a Therapeutic Target -- Cap-Adjacent m6Am and its Effects On mRNA -- N6-Methyladenosine in The Heart -- The m6a RNA Methylation Regulates Oncogenic Signaling Pathways Driving Cell Transformation and Carcinogenesis -- Psivar: A Database of Functional Variants Involved in Pseudouridylation (Ψ) with Implications for Disease Pathogenesis -- C-to-U RNA Editing by Mammalian APOBEC Enzymes -- The Powerful Mechanism of RNA Editing and its Therapeutic Potentials -- Noncanonical Caps in RNA -- Mass Spectrometry-Based Methods for Characterization of Hypomodifications in tRNA -- Dynamic mRNA Modifications in Plants -- The Mammalian Mitochondrial Epitranscriptome -- Epitranscriptomics Modifications of Micrornas: Classes, Detection, Impact on their Functionality and Next Frontiers -- "Look Before You Leap" when Editing the Introns, or the Secrets Behind the Intronic Post-Transcriptional Modification -- Functional Links Between the Internal N6-Methyl Adenosine Modifications in mRNAs and Human Diseases -- RNA Modifications in Neurodevelopment and Neurodegenerations -- Conventional and Advanced Techniques for Methyl-6-Adenosine Modification Mapping in Transcripts -- Mechanisms and Therapeutic Applications of RNA-Guided RNA Pseudouridylation -- Epitranscriptomic Modifications in lnRNA and miRNA in Cancer and Other Diseases -- RNA m6A and Adipogenesis. |
| Tipo de medio : |
Computadora |
| Summary : |
This book reviews a novel and exciting field of cellular and molecular biology called epitranscriptomics, which focuses on changes in an organism's cells resulting from the posttranscriptional modification of cellular RNA. RNA-binding proteins (RBPs) play a crucial role in these posttranscriptional modifications and also support several cellular processes necessary for maintaining RNA homeostasis. Exploring the mechanisms underlying RNA modifications and RBP function is an emerging area of biomedical research, taking the study of gene regulation a step beyond epigenetics. This book reveals that the RNA molecule is not just an information-carrying molecule with some secondary structures. Accordingly, how RNA is modified, regulated, packaged, and controlled is an important aspect. Leading experts address questions such as where the over 170 distinct posttranscriptional RNA modifications are located on the genome, what percentage of mRNAs and noncoding RNAs these modifications include, and how an RNA modification impacts a person's biology. In closing, the book reviews the role of RNA modifications and RBPs in a variety of diseases and their pathogenesis. Addressing some of the most exciting challenges in epitranscriptomics, this book provides a valuable and engaging resource for researchers in academia and industry studying the phenomena of RNA modification. |
| Enlace de acceso : |
https://link-springer-com.biblioproxy.umanizales.edu.co/referencework/10.1007/97 [...] |
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